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Abstract
The level of intracellular apoptosis regulators (cell death antagonists (Bcl-2) and agonists (CPP-32)), proliferation antigen Ki67 in lymphocytes of biopsy materials of the mucous coat of stomach at Helicobacter pylori-associated gastric ulcer and chronic gastritis in Khakassian aboriginal population and newcomers have been studied. The lymphocyte apoptosis in peripheral blood in aboriginal population was assessed. Changes in immunological indices were revealed in patients infected with Helicobacter pylori compared to healthy donors and newcomers. These changes were characterized by the more intense apoptotic lymphocyte death compared to the number of such cells in patients with chronic gastritis and in the control group. The role of apoptosis disfunctions in the regulation of local and system immunity at Helicobacter pylori infection is discussed.
Highlights
Исследован уровень внутриклеточных регуляторов апоптоза — антагонистов (Bcl-2) и агонистов (CPP-32) клеточной гибели, антиген пролиферации Ki-67 в лимфоцитах биоптатов слизистой оболочки желудка при Helicobacter pyloriассоциированных язвенной болезни и хроническом гастрите у коренных и пришлых жителей Хакасии
Changes in immunological indices were revealed in patients infected with Helicobacter pylori compared to healthy donors and newcomers
These changes were characterized by the more intense apoptotic lymphocyte death compared to the number of such cells in patients with chronic gastritis and in the control group
Summary
Роль апоптоза в дисрегуляции локального и системного иммунитета при Helicobacter pilory-инфекции. Changes in immunological indices were revealed in patients infected with Helicobacter pylori compared to healthy donors and newcomers These changes were characterized by the more intense apoptotic lymphocyte death compared to the number of such cells in patients with chronic gastritis and in the control group. При проведении эпидемиологического исследования распространенности язвенной болезни (ЯБ) у коренных и пришлых жителей Республики Хакасии было выявлено, что при высокой инфицированности Нр (95,4% среди европеоидов и 95,2% среди монголоидов) показатели заболеваемости среди представителей разных этнических популяций различаются (8,1 и 4,5% соответственно) [8]. Цель исследования — оценка апоптоза лимфоцитов слизистой оболочки желудка и периферической крови у европеоидов и монголоидов, проживающих на территории Хакасии, в условиях хронической персистенции Нр
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