Abstract

Immunophenotype profile of lymphocytes (CD3+, CD4+ and CD8+) from peripheral blood in gastric ulcer associated with Helicobacter pylori, chronic gastritis and stomach cancer has been studied in Khakassian aboriginals and migrants. Apoptosis of peripheral blood lymphocytes was also evaluated. Some alterations of immunological indexes were revealed in patients infected with Helicobacter pylori, as compared to healthy donors and migrants. The changes were characterized by a more intense apoptotic death of lymphocytes in the patients, when compared with numbers of apoptotic cells in control group. Probable role of apoptotic events in regulation of local and system immunity in Helicobacter pylori infection is discussed.

Highlights

  • Медицинская Иммунология ка из костномозговых стволовых клеток [14], что является свидетельством системных дисфункций иммунитета при длительном бактериальном носительстве

  • Immunophenotype profile of lymphocytes (CD3+, CD4+ and CD8+) from peripheral blood in gastric ulcer associated with Helicobacter pylori, chronic gastritis and stomach cancer has been studied in Khakassian aboriginals and migrants

  • Some alterations of immunological indexes were revealed in patients infected with Helicobacter pylori, as compared to healthy donors and migrants

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Summary

Краткие сообщения

Исследовали иммунофенотипический состав лимфоцитов (CD3+, CD4+ и CD8+) периферической крови при Helicobacter pylori-ассоциированных язвенной болезни, хроническом гастрите и раке желудка у коренных и пришлых жителей Хакасии. Immunophenotype profile of lymphocytes (CD3+, CD4+ and CD8+) from peripheral blood in gastric ulcer associated with Helicobacter pylori, chronic gastritis and stomach cancer has been studied in Khakassian aboriginals and migrants. Some alterations of immunological indexes were revealed in patients infected with Helicobacter pylori, as compared to healthy donors and migrants. Ранее нами при проведении эпидемиологического исследования распространенности язвенной болезни у коренных и пришлых жителей Хакасии было выявлено, что при высокой инфицированности H. pylori (95,4% среди европеоидов и 95,2% среди хакасов) показатели заболеваемости язвенной болезнью среди представителей разных этнических популяций различаются (8,1 и 4,5% соответственно) [9]. Целью настоящего исследования явилась оценка состояния системного иммунитета при хронической персистенции H. pylori у коренных и пришлых жителей Хакасии

Материалы и методы
Результаты и обсуждение
Больные РЖ
Доля клеток
Список литературы

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