Abstract
Breakage of medicinal tablets is a source of complaint and is an economic waste. It is desirable, therefore, to formulate and produce tablets which will survive handling in production and in distribution. Estimation of the ability of tablets to survive such handling has been difficult because of the lack of an adequate test to measure the property. A new apparatus which measures resistance to abrasion and shock has been designed. A weighed sample of tablets is subjected in the apparatus to a tumbling action and to the shock resulting from a free-fall of six inches. The loss of weight suffered is a measure of the friability of the tablets. The test has been found useful for the control of plain, compressed tablets, and especially for evaluating new formulations.
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More From: Journal of Pharmaceutical Sciences (Scientific Edition)
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