Abstract
In recent years, the research on stem cells has broadened people's knowledge of the occurrence and development of tumors. Nearly all tumors are related to stem cells，and stem cell markers have become the focus of current research. LGR5 is a type of leucine-rich repeat receptor (LGR), and studies confirm that LGR5 is expressed at various levels in the crypts of the floor of the small intestine, the crypts of the large intestine, the basal column cells of the gastric glands, and hair follicles. Therefore, LGR5 is one of the potential markers for cancer stem cells. LGR5 is a Wnt signaling ligand that plays an active role in ontogeny. LGR5's binding partner, R-spondin (RSPO), can control Wnt signaling along with LGR5. This article analyzes the signaling pathways of LGR5 in tumor stem cells, summarizes the role of LGR5 there, and points out future research directions.
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