Abstract

It has been reported that desensitization of the motor endplate, during prolonged application of acetylcholine, is associated with a marked shift in the ‘reversal potential’, interpreted as a change in ion selectivity of the permeable endplate channels. The matter has been re-examined by direct determination of reversal potentials, avoiding the linear extrapolation on which previous estimates were based. The present results show no sig­nificant alteration of the reversal potential ascribable to desensitization.

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