The return of the spike: postsynaptic action potentials and the induction of LTP and LTD.

Abstract

. Formulated to ex- renewed interest in postsynaptic spiking and synapticplain how memories could be stored as alterations in plasticity and have refocused attention on the literalsynaptic strength, it reads: interpretation of Hebb’s postulate. The basic obser-vation that sparked this new era was the conclusiveWhen an axon of cell A is near enough to excite a cell demonstration (with simultaneous whole-cell patch re-B and repeatedly or persistently takes part in firing it, cordingataxonal, somatic,anddendriticloci onasinglesome growth process or metabolic change takes neuron) that Na