Abstract
Relationships between R M values and mobile phase composition have been determined for the six antihyperlipidemic agents-bezafibrate, ciprofibrate, clofibrate, clofibric acid, fenofibrate, and gemfibrozil. The drugs were separated on silica gel, CN, and Diol plates using mobile phases containing n -hexane as weakly polar diluent and five polar modifiers: acetone, dioxane, ethyl methyl ketone, ethyl acetate, and tetrahydrofuran. The optimum mobile phases were also investigated on alumina, NH 2 , and polyamide phases for comparison. The linearity of relationships between R M and modifier volume fraction, molar fraction, and logarithm of molar fraction was calculated. Plates were developed in horizontal chambers, visualized under UV irradiation at λ = 254 nm, and scanned with a densitometer in the multi-wavelength scan mode. Most results fitted the Snyder-Soczewinski equation with r > 0.9; for approximately half r > 0.99. Separation of all the drugs was achieved on Diol plates with mobile phases containing 2...
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