The response to anti-TNF ab therapy is variable in patients with psoriasis.

Abstract

Event Abstract Back to Event The response to anti-TNF ab therapy is variable in patients with psoriasis. Kazuhiro Komura1* 1 Municipal Tsuruga Hospital, Japan Psoriasis is a proliferative epidermal disorder with immunological background. While some monoclonal antibody therapies against immune mediators are available for the patients, efficacy of the therapy is highly variable. We describe the diversity of anti-TNF ab effects against the psoriasis patients. We treated 7 psoriasis patients by anti-TNF ab. The therapy was effective for 5 patients, while it was not effective for 1 patient. One patient developed pneumocystis carinii pneumonia after the therapy. The TNF resistant was successfully treated by IL23 blocker. However, there was no sign or specific clinical features in this patient, when compared to other patients who were improved by TNF therapy. Although it was unclear in this study, the identification of genetic and/or disease variants has the potential to improve the selection of the drug. A suitable approach in implementing such a strategy could potentially reduce medical costs and improve success of drug therapy. Since ~20% of patients do not respond to TNF therapy, we may focus on these patients and TNF related molecules. Further, the evaluation might include experimental/preclinical studies, using patient own skin/immune cells and candidate drugs. Thus, personalized medicine will mandate special physicians capable of understanding molecular medicine in addition to genetics and biomarkers for diagnosis, evaluation of the effect of drugs, and overall prognosis. Figure 1 Keywords: Psoriasis, Tumor Necrosis Factor-alpha, personalized medicine, IL-23, Cost Control Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: Komura K (2013). The response to anti-TNF ab therapy is variable in patients with psoriasis.. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00137 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Kazuhiro Komura, Municipal Tsuruga Hospital, Tsuruga, Japan, komuraka@me.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kazuhiro Komura Google Kazuhiro Komura Google Scholar Kazuhiro Komura PubMed Kazuhiro Komura Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.