Abstract
To improve the accuracy of quartz crystal microbalance (QCM) immunosensor, it is the key to distinguish accurately and effectively about the effects of mass loading and damping loading of a quartz resonator vibrating in damping environment. The energy transfer model (ETM) is introduced to deduce functional relationship between the product of absolute viscosity and density of the liquid deposit and the maximum amplitude of vibration at the quartz-resonator surface. Then the effect of mass loading can be rapidly distinguished from damping loading by measuring the frequency shift and the amplitude of QCM. This method provides a new theoretical basis for the application of QCM immunosensor in medical diagnosis, especially in tumor diagnosis.
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