Abstract
1. Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred.2. The release of both substances is increased by arachidonic acid and inhibited by aspirin-like drugs.3. When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines.4. RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins.
Full Text
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call