Abstract
BackgroundThis study aims to investigate the association between handgrip strength (HGS) and cardiometabolic disorders (CMD), including hypertension, diabetes, and dyslipidemia, in a prospective study.MethodsThe association between HGS and CMD was examined using the data from 5,271 Chinese adult participants ≥45 years old enrolled in the CHARLS (Chinese Health and Retirement Prospective Cohort Study) during 2011–2015. Relative HGS, calculated as maximal absolute HGS from both hands divided by body mass index, was used in the primary analysis and divided into three groups according to the tertiles (T1, T2, and T3).ResultsThe participants with higher relative HGS had a lower risk of hypertension, diabetes, and dyslipidemia than those with lower HGS, although did not reach statistical significance for diabetes and hypertension in males. Participants with higher HGS had significantly lower risk of hypertension [T3 vs. T1: OR = 0.69, 95% CI = 0.51–0.91, P = 0.010] and dyslipidemia (OR = 0.65, 95% CI = 0.51–0.83, P < 0.001) in males. For females, participants with higher HGS had significantly lower risks of dyslipidemia (OR = 0.67, 95% CI = 0.54–0.83, P < 0.001).ConclusionA consistent association was observed between higher relative HGS and lower risk of CMD. Further research is required to evaluate whether relative HGS can be a convincing predictor for the occurrence of CMD and as a target for intervention in the high-risk population.
Highlights
Cardiometabolic disorders (CMD), including hypertension, diabetes, dyslipidemia, and cardiovascular disease, have been a leading cause of death in China and around the world (Yang Z.J. et al, 2012; GBD 2016 Causes of Death Collaborators, 2017; Lu et al, 2018)
We investigated the associations between handgrip strength (HGS) and CMD using maximal absolute HGS and mean HGS of both hands (BMI was adjusted for in the models)
The baseline characteristics of the participants were presented according to the relative HGS tertiles (Table 1)
Summary
Cardiometabolic disorders (CMD), including hypertension, diabetes, dyslipidemia, and cardiovascular disease, have been a leading cause of death in China and around the world (Yang Z.J. et al, 2012; GBD 2016 Causes of Death Collaborators, 2017; Lu et al, 2018). Peterson et al (2017) analyzed the data from the U.S National Health and Nutrition Examination Survey 2011–2012 and 2013–2014 combined surveys, and the 2011 wave of the China Health and Retirement Longitudinal Study, and found that normalized HGS was robustly associated with both CMD and physical disabilities in the United States and Chinese aging adults Another cross-sectional data using the 2013 National Physical and Health in Shanxi Province involving 5,520 participants found that HGS was associated with metabolic profiles and a higher risk of metabolic diseases (Li et al, 2018). This study aims to investigate the association between handgrip strength (HGS) and cardiometabolic disorders (CMD), including hypertension, diabetes, and dyslipidemia, in a prospective study
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