Abstract
The mathematical relationships between the volume and composition of blood and plasma have been reviewed. It has been shown that misunderstanding of these relationships can lead to misinterpretation of results. In a review of published data on plasma protein concentration (PP) and packed cell volume (PCV) during dehydration, the expected greater increase in plasma protein concentration was usually observed. Unexpected values were explained by a variety of factors affecting PCV and PP. Discrepancies between plasma volume changes calculated from PP or PCV and blood haemoglobin concentration can provide useful information. Changes in mean corpuscular volume were inversely related to changes in plasma osmolality. In dehydrated animals, accurate interpretation of data is often limited by the lack of predisease baseline values.
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