THE RELATIONSHIP OF ENA PROFILE AND SOME NEW IMMUNOLOGICAL MARKERS IN LUPUS NEPHRITIS PATIENTS IN KERBALA PROVINCE

Abstract

Lupus nephritis is an immune complex Glomerular Nephritis (GN) that develops as a frequent complication of SLE, the pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The external etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear auto antigens, the increased incidence of ESRD underlines the importance of early diagnosis in this difficult to control disease with unpredictable course This study aimed to distinguished between the patients with primary glomerulonephritis from the secondary glomerulonephritis (SLE) by using the Phospholipase A2 receptor test (PLA2R), and aimed to use the ENA screen test to detect The patients with naïve SLE from the patient with SLE associated with other autoimmune disease, also measurement the the concentration of NGAL, VCAM, ANA, ds-DNA by using ELISA method, this research included eighty-five female patients.