Abstract
Angiotensin II (AII) produced by Renin-Angiotensin-Aldosterone System (RAAS) through the classical pathway have been associated with the regulation of adipocyte glycolytic and lipolytic metabolism. This pathway can be potentiated by the increase of catecholamines. The Wistar-Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR) strains exhibet high catecholamines pattern and have different adipocyte profiles. This work aims to evaluate the influence of AII in the production of glycerol and lactate from these different strains.
Highlights
Lipolytic and glycolytic activity are regulated by catecholamines, which act on the availability of stored energy, which are involved with the ReninAngiotensin-Aldosterone System (RAAS) activation, responsible for angiotensin II (AII) production in the classic pathway [1,2]
The lipolytic activity does not exhibit any difference in the basal production; AII seems to have anti-lipolytic in WKY isolated adipocytes
The glycolytic metabolism of the adipocyte is not affected by AII
Summary
Lipolytic and glycolytic activity are regulated by catecholamines, which act on the availability of stored energy, which are involved with the ReninAngiotensin-Aldosterone System (RAAS) activation, responsible for angiotensin II (AII) production in the classic pathway [1,2]. The AII may be related to lipolysis and glycolysis modulation in adipose tissue, where the AT1 and AT2 receptors blockade affect the adipocyte metabolism [3]. The Spontaneously Hypertensive Rats (SHR), as its control Wistar-Kyoto (WKY), exhibit high catecholamines pattern and different weights and adipocytes profiles, which WKY is heavier, with higher area and diameter of their adipocytes [4]. This work aims to evaluate the influence of AII in the production of glycerol and lactate from these different strains
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