The Relationship Between Thyroid Function and T Lymphocyte Subsets in Patients with Hashimoto's Thyroiditis

Abstract

<i>Objective</i>: To assess the relationship between thyroid function and T lymphocyte subsets in Patients with Hashimoto's Thyroiditis. <i>Method</i>: To select 131 diagnosed HT patients as the research object, which is divided into HT hyperthyroidism group (Group A) with 18 cases, normal HT thyroid function group (Group B) with 35 cases, HT subclinical hypothyroidism group (Group C) with 42 cases, and HT hypothyroidism group (Group D) with 36 cases in accordance with thyroid function. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, and FCM is adopted to test T lymphocyte subsets. <i>Result</i>: Compare CD3⁺T lymphocytes of each group, Group D is obviously higher than Group A, Group B, and the control group, and the difference has statistic significance (P<0.05); Compare CD3⁺CD4⁺T lymphocyte and CD4⁺/CD8⁺ of each group, Group D is obviously higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group A and Group B are obviously higher than the control group, and the differences have statistic significance (P<0.05); Compare CD3⁺CD8⁺T lymphocytes of each group, Group D is obviously lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, the difference has statistic significance (P<0.05). The correlation analysis shows that TSH is in positive correlation with CD4⁺/CD8⁺, FT3 is in positive correlation with CD3⁺CD8⁺T, and FT4 is in positive correlation with CD3⁺CD8⁺T and in negative correlation with CD4⁺/CD8⁺. <i>Conclusion</i>: HT patients have the imbalance of T lymphocyte subsets, and the T lymphocyte subsets ratio of HT patients of different thyroid function has obvious differences, which may have close relationship with the occurrence and development of HT.