Research on Renal Injury in Hashimoto&amp;apos;s Thyroiditis Patients with Different Thyroid Function

Rongqin Dai,Jinbiao Zhang,Ying Li,Chao Shen Zhang,Yang Chen,Qian Xu

doi:10.11648/j.sjph.20210903.16

Abstract

Objective: To assess the relationship between thyroid function and renal injury in Patients with Hashimoto's Thyroiditis. Method: To select 156 diagnosed HT patients as the research object, according to whether there is renal injury, they were divided into renal injury group with 21 cases and non-renal injury group with 135 cases. According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases. Besides, 40 cases of healthy check-up people are selected as the control group. ECLIA is adopted to test the thyroid function index of each group, Serum cystatin C and 24-hour urinary microalbumin were measured by immunoturbidimetry, serum creatinine was measured by creatine oxidase method, and the endogenous creatinine clearance rate was calculated. Result: TSH, TPOAb and TGAb in renal injury group were distinctly higher than those in non-renal injury group, while FT3 and FT4 were distinctly lower than those in non-renal injury group; Comparison of serum creatinine in Hashimoto groups, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, Group B is obviously higher than Group A, Group A is significantly lower than other groups; Comparison of cystatin C and creatinine clearance of each group, Group D is significantly lower than other groups, Group C is obviously lower than Group A, Group B, and the control group, Group B is obviously lower than Group A, Group A is significantly higher than other groups; Comparison of 24-hour urinary microalbumin of each group, Group D is significantly higher than other groups, Group C is obviously higher than Group A, Group B, and the control group, and the differences have statistic significance (P<0.05). The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance; TSH, TPOAb, TGAb is in positive correlation with 24-hour urinary microalbumin. Conclusion: There are obvious differences in renal function indexes of HT patients with different thyroid function states, which may be related to the effect of thyroid hormones and autoantibodies.

Highlights

Autoimmune thyroid diseases (AITD) mainly include Hashimoto's thyroiditis (HT), Graves disease, autoimmune atrophic thyroiditis, postpartum thyroiditis, painless thyroiditis, thyroid associated ophthalmopathy, etc [1]
According to the thyroid function, they were divided into HT hyperthyroidism group (Group A) with 19 cases, normal HT thyroid function group (Group B) with 37 cases, HT subclinical hypothyroidism group (Group C) with 61 cases, and HT hypothyroidism group (Group D) with 39 cases
The correlation analysis shows that FT3, FT4 are in negative correlation with serum creatinine and in positive correlation with cystatin C and creatinine clearance, TSH, Thyroid peroxidase antibody (TPOAb), Thyroglobulin antibody (TGAb) is in positive correlation with 24-hour urinary microalbumin. (Table 3)

Summary

Introduction

Autoimmune thyroid diseases (AITD) mainly include Hashimoto's thyroiditis (HT), Graves disease, autoimmune atrophic thyroiditis, postpartum thyroiditis, painless thyroiditis, thyroid associated ophthalmopathy, etc [1]. Graves disease and HT are the most common in the clinic [2]. As confirmed in previous studies, thyroid and renal are closely related, coordinate and influence each other [3]. There are frequent reports that renal injury caused by thyroid disease is misdiagnosed as diabetic nephropathy, primary nephrotic syndrome, lupus nephritis and interstitial nephritis. If kidney damage caused by thyroid disease can be early detected and the primary disease can be actively treated, the prognosis of kidney damage is good, and renal function can be partially or completely restored. AITD is an organ specific autoimmune disease. The immune function of patients is abnormal.

Methods

Results

Conclusion