Abstract
The effect of small doses of cyclohex-imide (CH) (0.5 µg/g body wt) on the intrathyroid metabolism of carrier-free 13II and stable iodide iniodine-sufficient and iodine-deficient rats and on thyroglobulin (Tgb) maturation in iodine-deficient rats was studied. This dose of CH had no apparent toxicity but strikingly inhibited the incorporation of l4C-labeled amino acids into thyroid and plasma proteins. In iodine-sufficient rats, CH did not affect T/S (I−) ratios, but did enhance the sensitivity of the thyroid to the acute inhibitory effects of stable iodide on the organification mechanism (Wolff-Chaikoff effect). CH produced unusual effects on the intrathyroid metabolism of 131I in these iodine-sufficient rats: a decrease in 13II uptake, an increase in labeled DIT and a decrease in MIT so that MIT/DIT ratio declined, and a decrease in the proportionate synthesis of the iodothyronines T4 and T3. In iodine-deficient rats, CH also sensitized) the thyroid to the acute Wolff-Chaikoff effect but produced changes...
Published Version
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