Abstract
ABSTRACT Objective The use of opioid substances during pregnancy, including heroin and methadone, is associated with adverse outcomes. This study aims to investigate the relationship between maternal opioid use and factors related to neonatal health at birth in Iran in 2022. Methods This was a case-control study conducted with 206 mothers (103 with opioid use disorder and 103 without). Data concerning maternal health were collected via questionnaires, while neonatal health information was obtained from maternal medical records. Data analysis was performed using Pearson correlation, independent t-tests, multiple regression, and descriptive statistics. Results The average APGAR score one minute after birth was 8.94 ± 0.23 in the group of mothers with opioid use disorder and 8.98 ± 0.19 in the group without opioid use disorder. No statistically significant difference was found between the two groups regarding APGAR scores at one minute and five minutes after birth (p > 0.05). A multiple regression analysis revealed a significant statistical relationship between maternal opioid use and neonatal weight, height, and head circumference (R = 0.71, p < 0.001). Conclusion Significant differences were observed between mothers with opioid use disorder and those without in terms of neonatal weight, head circumference, and height.
Published Version
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