Abstract
Objective. The aim of this work was to study the impact of seasons on the incidence of the experimental arterial hypertension. Design and methods . We applied the model of vasorenal hypertension “2 kidney, 1 clip” in Wistar male rats in standard laboratory conditions. We compared the following parameters in the groups with clipped arteries in autumn, winter and spring: systolic blood pressure, beat-to-beat interval, low- and high-frequency components of heart rate variability. Results. The risk of vasorenal hypertension occurrence was higher in spring (56 %). More seldom vasorenal hypertension developed in winter (20 % of animals), and an increase in density of low and high-frequency components of heart rate variability was observed after applying renal artery clamp in the winter group. There was a clear correlation between an increase in the average monthly variability of atmospheric pressure and a decrease in the frequency of vasorenal hypertension occurrence. Conclusions. We conclude that the season has an impact on the development of hypertension, which probably is due to the seasonal changes in sympathetic and parasympathetic activity. We assume that clear seasonal dynamics of atmospheric pressure variability causes the seasonal variations in the functioning of the cardiovascular and autonomic nervous systems in standard laboratory conditions.
Published Version
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