Abstract
目的 探讨血管内皮生长因子(VEGF)、P53和细胞增殖核抗原(PCNA)蛋白表达与垂体腺瘤的侵袭性和复发的关系.方法应用免疫组化染色方法检测VEGF、P53和PCNA蛋白在30例侵袭性垂体腺瘤及30例非侵袭性垂体腺瘤中的表达.结果侵袭组中VEGF和PCNA蛋白的表达阳性率分别为16/30 (53.3%)和13/30 (43.3%),非侵袭组中分别为8/30 (26.7%)和5/30 (16.7%),两种蛋白的表达水平侵袭组明显高于非侵袭组(P 0.05),但第二次手术组则明显高于非复发组(P<0.01).结论 VEGF、P53和PCNA蛋白异常表达与垂体腺瘤的发生、侵袭和复发改变有关,检测这3项指标可对肿瘤侵袭和预后进行评价。
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