The correlation of p53,PCNA and VEGF protein expression with tumor prognosis in bladder transitional cell carcinoma

Abstract

Objective To study the correlation of p53,PCNA and VEGF protein expression and other recurrence factors with tumor prognosis，and its clinical significance in bladder transitional cell carcinoma(BTCC).Methods The retrospective survival analysis of BTCC patients and their age，sex，clinical staging，parameters of tumor grade，number of tumors，whether keep intravesical chemotherapy，expression of p53，VEGF and PCNA were performed by chi-square test,Cox proportional hazard model.Results On univariate analysis，the parameters of tumor grade,clinical staging,operative methods,the expression of p53 protein and VEGF protein,number of tumors and whether keep intravesical chemotherapy after operation were significant for tumor recurrence(all P<0.05).On multivariate analysis of Cox proportional hazard model,the risk factors for tumor recurrence were tumor stage(RR=4.162，P=0.001)，the expression of p53 protein(RR=2.913，P=0.038),the expression of VEGF protein(RR=3.316，P=0.010),long time intravesical chemotherapy after operation will improve the therapeutic effect of BTCC(RR=0.217，P=0.000).Conclusions Clinical staging,p53 and VEGF protein expression is an important yet imperfect evaluation of patients with bladder cancer,aside from the key roles,tumor grade is closely correlated with the risk of developing bladder cancer.Further intravesical therapy also has an associated improved survival.