THE RELATIONSHIP BETWEEN SERUM FGF-23 CONCENTRATION AND CLINICAL AND SUBCLINICAL FACTORS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

Objective: To evaluate the relationship between serum FGF-23 levels and other factors affecting bone mineral disorders in chronic kidney disease. Method: Cross-sectional study, describe and analyze of the relationship between FGF-23 and biochemical parameters, clinical characteristics of 149 patients with chronic kidney disease. Results: For conservative group, FGF-23 level correlated positively with level of urea, creatinine and inversely correlated with glomerular filtration rate (GFR); the level of urea, creatinine and GFR are the three most influential factors on FGF-23 level, the changes in level of urea, creatinine and GFR explain 30.6% and 29.5% and 11.2% respectively of change in FGF-23 level with p < 0.05. For hemodialysisgroup, there is a positive correlation between the level of FGF-23 and the level of total calcium, Phosphorus and calcium-phosphorus accumulation; Total calcium, Ca x P level are the twoo most influential factors on the level of FGF-23, total calcium changes, Ca x P explain 29.7% and 18.8% respectively of change in FGF-23 level with p < 0.05. Conclusion: There is a strong correlation between FGF-23 levels and factors affecting bone mineral disorders in patients with chronic kidney disease. Key words: chronic kidney disease, fibroblast growth factor 23