Update on the treatment of osteoporosis

Abstract

Osteoporosis is a common bone disease, especially in the elderly and post-menopausal women. Osteoporosis increases mortality and comorbidities. In recent years, a profound understanding of the pathogenesis has contributed to the development of new effective therapies in the treatment of osteoporosis. In addition to the anti-resorptive drug groups such as bisphosphonates, which have been used for a long time, the group of anabolics agents such as PTH or recently approved Romosozumab make the treatment of this disease more advantageous. The purpose of this review is to present advances in osteoporosis therapies. Content includes risk factor assessment, non-pharmacological and pharmacological therapies in the treatment of osteoporosis. The review will also discuss treatment options including their mechanism, safety profile, effectiveness on bone density and fracture risk, and duration of use. A comprehensive understanding of new therapies will make the treatment of osteoporosis more effective. Key words: Osteoporosis, post-menopausal, bisphosphonates.