The relationship between semen parameters in processed and unprocessed semen with intrauterine insemination success rates

Leila Mollaahmadi,Ashraf Ghiasi,Afsaneh Keramat,Mozhgan Hashemzadeh

doi:10.4274/jtgga.galenos.2018.2018.0089

Leila Mollaahmadi, Ashraf Ghiasi + Show 2 more

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https://doi.org/10.4274/jtgga.galenos.2018.2018.0089

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Abstract

Objective:To evaluate the relationship between semen parameters and intrauterine insemination (IUI) success rates.Material and Methods:This retrospective study was conducted during a 4-year period (2011-2015) on the medical records of 350 couples admitted to the infertility center of Beast Hospital in Tehran. The participants’ data such as age, duration of infertility, semen parameters [including volume, concentration, motility, normal morphology and total motile sperm count (TMSC)] before and after sperm processing, as well as the IUI results were extracted from the patients’ records. Only the first IUI cycle of the couples was considered. The main outcome criterion for the IUI success was serum positive beta human chorionic gonadtotropin 14 days after IUI. The collected data were analyzed using the Mann-Whitney U test, chi-square, and Fisher’s exact tests.Results:The overall pregnancy rate for each couple was reported as 23.42% (82/350). There was no significant difference in the mean age of the couple and infertility duration between the groups who achieved pregnancy and those who failed. The two groups showed no significant differences in pre and post processing of semen parameters (including volume, concentration and TMSC). Sperm motility and normal sperm morphology before and after sperm processing were significantly different between the two groups, respectively (p=0.023 before sperm processing and p=0.032 after) (p=0.032 before sperm processing and p=0.007 after).Conclusion:Sperm motility and normal sperm morphology have an effect in IUI success.

Highlights

Infertility is defined as the failure to conceive after one year of regular intercourse, without the use of contraceptives
There was no significant difference in semen parameters including sperm volume, sperm concentration and total motile sperm count (TMSC) before and after sperm processing between the two groups (Table 3)
The results of our study showed that the pregnancy rate with intrauterine insemination (IUI) was 23.4% for each couple (82/350)

Summary

Introduction

Infertility is defined as the failure to conceive after one year of regular intercourse, without the use of contraceptives. The use of techniques such as intrauterine insemination (IUI) in conjunction with controlled ovarian stimulation have increased the hope for pregnancy in infertile couples. IUI is the first-line treatment, a non-invasive and cost effective procedure for the treatment of infertile couples and is performed by inserting a higher concentration of prepared sperms into the uterine cavity [2,3]. Semen analysis is the first step in the evaluation of male infertility because male factors account for 25 to 40% of infertility cases [4]. In these assessments, semen characteristics including volume, sperm concentration, sperm motility, and normal sperm morphology are usually evaluated. Normal sperm morphology: 4% [5,6]

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Conclusion