Abstract
Sarcopenia is a progressive and generalized syndrome that can be linked to many causes such as cancers, and is caused by a quantitative and qualitative disorder (loss of muscle strength and/or physical performance) of skeletal muscle mass. Although sarcopenia has some hypothetical explanation in clinical practice, the mechanisms underlying this condition have not been clearly differentiated in patients with cancer. We aimed to investigate the relationship between irisin, FGF21 and CRP in detecting sarcopenia in colorectal cancer patients. Current prospectively study included non-metastatic newly diagnosed colorectal cancer patients. Patients were divided into 2 groups of 25 people, those with and without sarcopenia. Body composition measurements by examined by BIA. To measure the level of iris and FGF21 from patients, blood samples were taken into the biochemistry tube and their levels were measured. The median age of the patients included in the study was 60years (range: 21-81), 68% were men. It was found that there was a significant relationship between sarcopenia and gender and BMI measurement. When Spearman correlation analysis was performed between skeletal muscle mass index and FGF21, irisin and CRP, there was a positive correlation between skeletal muscle mass index and irisin and FGF21, while there was a negative correlation between skeletal muscle mass index and CRP. [respectively: (r: 0.282, p: 0.048), (r: 0.564, p: < 0.001) and (r: - 0.360, p: 0.010)]. Similar results were found between hand-grip strength and FGF21, irisin and CRP. [respectively: (r: 0.342, p: 0.015), (r: 0.290, p: 0.041) and (r: - 0.476, p < 0.001)]. When sarcopenia was treated as the dependent variable in the logistic regression analysis, and FGF21, irisin, CRP, gender and BMI were treated as the independent variables, irisin and CRP levels were determined as independent predictors. This study was revealed that there is a negative relationship between sarcopenia and irisin and FGF-21 in operated non-metastatic colorectal cancer patients and there may be a relationship between sarcopenia and inflammation. It suggests that these biomarkers may play a role in the pathophysiology of sarcopenia. However, our results need to be validated in different types of cancer and with more patients.
Highlights
As defined by the European Society of Parenteral and Enteral Nutrition (ESPEN) and the European Working Group on Sarcopenia in Older People (EWGOSP), sarcopenia is a syndrome characterized by progressive and generalized muscle loss, which can be associated with a wide range of causes and may lead to falls, physical injuries, treatment complications, as well as negative impacts on survival, and accompanied by quantitative and qualitative deterioration of the skeletal muscle mass [1, 2].Many functional tools are recommended by international workgroups to identify the quantitative muscle mass [1–3]
When Spearman correlation analysis was performed between skeletal muscle mass index and FGF21, irisin and CRP, there was a positive correlation between skeletal muscle mass index and irisin and FGF21, while there was a negative correlation between skeletal muscle mass index and CRP. [respectively: (r: 0.282, p: 0.048), (r: 0.564, p:
Similar results were found between hand grip strength and FGF21, irisin and CRP. [respectively: (r: 0.342, p: 0.015), (r: 0.290, p: 0.041) and (r: -0.476, p
Summary
Many functional tools are recommended by international workgroups to identify the quantitative muscle mass [1–3] These include bio-electric impedance analysis (BIA), computed tomography (CT), dual x-ray absorptiometry (DXA) and magnetic resonance imaging (MRI). Many studies have concluded that irisin levels in circulation are related to fat-free mass and to muscle strength and function [11, 12]. All these findings suggest a positive connection between irisin and muscle physiology and metabolism, and that irisin has a potential regulatory role [11, 13] (15,25). The relation between irisin levels and sarcopenia developed by cancer patients has not been explicated
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