Abstract
BackgroundProgression of plantar flexor weakness in neuromuscular diseases is usually monitored by muscle strength measurements, although they poorly relate to muscle function during walking. Pathophysiological changes such as intramuscular adipose tissue affect dynamic muscle function independent from isometric strength. Diffusion tensor imaging and T2 imaging are quantitative MRI measures reflecting muscular pathophysiological changes, and are therefore potential biomarkers to monitor plantar flexor functioning during walking in people with neuromuscular diseases. MethodsIn fourteen individuals with plantar flexor weakness diffusion tensor imaging and T2 scans of the plantar flexors were obtained, and the diffusion indices fractional anisotropy and mean diffusivity calculated. With a dynamometer, maximal isometric plantar flexor strength was measured. 3D gait analysis was used to assess maximal ankle moment and power during walking. FindingsFractional anisotropy, mean diffusivity and T2 relaxation time all moderately correlated with maximal plantar flexor strength (r > 0.512). Fractional anisotropy and mean diffusivity were not related with ankle moment or power (r < 0.288). T2 relaxation time was strongly related to ankle moment (r = −0.789) and ankle power (r = −0.798), and moderately related to maximal plantar flexor strength (r < 0.600). InterpretationIn conclusion, T2 relaxation time, indicative of multiple pathophysiological changes, was strongly related to plantar flexor function during walking, while fractional anisotropy and mean diffusivity, indicative of fiber size, only related to maximal plantar flexor strength. This indicates that these measures may be suitable to monitor muscle function and gain insights into the pathophysiological changes underlying a poor plantar flexor functioning during gait in people with neuromuscular diseases.
Highlights
This study aimed to 1) determine whether Mean Diffusivity (MD), Fractional Anisotropy (FA) and T2 transverse relaxation time (T2) relaxation time differ between persons with a minimal and severly reduced ankle moment during walking due to plantar flexor weakness and 2) whether these parameters relate with isometric plantar flexor strength and maximal ankle moment and ankle power in adults with slowly pro gressive neuromuscular diseases (NMD)
We demonstrated that in people diagnosed with NMD and slowly progressive plantar flexor weakness, T2 relaxation time was the only quantitative Magnetic Resonance Imaging (MRI) measure that differed between plantar flexors with a minimally reduced and severely reduced ankle moment
T2 relaxation time strongly related with ankle moment and power, while MD and FA were not
Summary
The plantar flexors are essential for an efficient gait pattern (Waterval et al, 2018). Interpretation: In conclusion, T2 relaxation time, indicative of multiple pathophysiological changes, was strongly related to plantar flexor function during walking, while fractional anisotropy and mean diffusivity, indicative of fiber size, only related to maximal plantar flexor strength. This indicates that these measures may be suitable to monitor muscle function and gain insights into the pathophysiological changes underlying a poor plantar flexor functioning during gait in people with neuromuscular diseases
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