The relationship between nonalcoholic fatty liver disease with visceral fat depots of other localization, metabolic parameters and markers of renal dysfunction in patients with obesity

Abstract

Background and Aims : To assess the relationship between non-alcoholic fatty liver disease (NAFLD) with visceral fat, metabolic parameters, markers of renal dysfunction in patients with obesity.Methods: The study included 105 people aged 44.8±6.4 years. The group №1-patients with NAFLD, BMI 36.1±3.2kg/m2. The group №2- without NAFLD with BMI 35.5±3.9kg/m2. The TNF, β2 microglobulin, ACRU, IL 6, MCP-1, leptin, resistin and cystatin C was determined by ELISA. GFR was calculated by CKD-EPI formula and cystatin C. The examination of visceral adipose tissue: VAT- measurement at the level of the navel from the inner surface of the rectus abdominis to the posterior wall of the aorta and L4; the thickness of the posterior perirenal fatty tissue and perirenal fatty tissue on both sides.Conclusions: In patients with NAFLD, the parameters of the lipid profile and renal dysfunction deteriorate, which can contribute to the development of atherosclerosis. Background and Aims : To assess the relationship between non-alcoholic fatty liver disease (NAFLD) with visceral fat, metabolic parameters, markers of renal dysfunction in patients with obesity. Methods: The study included 105 people aged 44.8±6.4 years. The group №1-patients with NAFLD, BMI 36.1±3.2kg/m2. The group №2- without NAFLD with BMI 35.5±3.9kg/m2. The TNF, β2 microglobulin, ACRU, IL 6, MCP-1, leptin, resistin and cystatin C was determined by ELISA. GFR was calculated by CKD-EPI formula and cystatin C. The examination of visceral adipose tissue: VAT- measurement at the level of the navel from the inner surface of the rectus abdominis to the posterior wall of the aorta and L4; the thickness of the posterior perirenal fatty tissue and perirenal fatty tissue on both sides. Conclusions: In patients with NAFLD, the parameters of the lipid profile and renal dysfunction deteriorate, which can contribute to the development of atherosclerosis.