Abstract
Diabetes and Nonalcoholic Fatty Liver Disease
Highlights
It is why a concerted effort of the academic disciplines is requested to study the responsible mechanisms involved in the process of hepatic fat accumulation as well as the mechanisms regulating the crosstalk between fatty liver and other tissues important for regulation of metabolism in humans
With almost every third individual affected in the general population in industrialized countries and increasing prevalence among children and adolescents, nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver diseases such as cirrhosis, liver failure, and hepatocellular carcinoma and is the most common cause of liver transplantation
The authors focused on the liver, where a lot of transcription factors have key roles in metabolic pathways critical for the pathogenesis of hepatic insulin resistance and NAFLD
Summary
It is why a concerted effort of the academic disciplines is requested to study the responsible mechanisms involved in the process of hepatic fat accumulation as well as the mechanisms regulating the crosstalk between fatty liver and other tissues important for regulation of metabolism in humans. Several studies demonstrate that NAFLD is strongly associated with insulin resistance and precedes the manifestation of type 2 diabetes and cardiovascular disease.
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