THE RELATIONSHIP BETWEEN NK AND NATURAL ANTIBODY TARGET STRUCTURES

Abstract

Publisher Summary This chapter focuses on the relationship between natural killer (NK) and natural antibody target structures. It has become apparent that a relationship exists between the tumor target structures recognized by natural antibody and NK cells. It was found that rabbit natural antibody preferentially lysed NK sensitive tumors in the presence of complement, and that RNAb anti-YAC-1 was absorbed by tumors in a manner corresponding to their NK sensitivity. The relationship of murine NAb and RNAb to NK lytic sensitivity leads one to speculate that the target structures of these effectors might be the same, or coexpressed on the membrane. A dissociation of the expression of NAb and NK TS was noted when examining the membrane modulation induced by treatment with interferon. NK sensitivity of the SL2-5 was profoundly inhibited by small doses of interferon, while both RNAb- and MNAb-mediated lysis were enhanced. This inverse relationship of NK and NAb was similar to that identified earlier when comparing the reactivity of SL2 clones. The YAC-1 tumor, on the other hand, exhibited a slight decrease in NK sensitivity and RNAb lysis after IFN treatment while MNAb lysis rose significantly.