Abstract
Publisher Summary This chapter reviews studies on the regulation of tumor growth by natural killer (NK) cells in nude mice. Repeated injection of anti-asialo GM1 (anti-GAl) every three days into mice maintain the NK activity at less than 5% level and abrogated GA1+ cells in the spleen without elimination of T and B cells. It was judged adequate for study of the biological role of NK cells in vivo. Two million syngeneic tumor cells, RL♂-1 or two million allogeneic tumor cells, YAC-1, were subcutaneously injected into each BALB/c nude mouse on the same day, and each mouse also received intravenous injection of rabbit anti-GAI or normal rabbit serum (NRS). For a duration of 24 days, each mouse received repeated injections of the antiserum every three days and the size of palpable tumors was recorded. 100 percent palpable tumor of RL♂-1 appeared in anti-GAl injected mice, whereas the tumors were detectable less than 25% of mice injected with normal rabbit serum (NRS).
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