THE RELATIONSHIP BETWEEN NEUTROPHİL / LYMPHOCYTES RATIO AND PLATELET / LYMPHOCYTES RATIO WITH PROGNOSIS IN OPERATED STAGE 1-2 OF NON- SMALL CELL LUNG CANCER DISEASE: ONE CENTRAL EXPERIENCE

Abstract

Aim: The relationship between neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) and the prognosis of various cancers has been demonstrated. However, the impact of NLR and PLR on the prognosis of non-small cell lung cancer (NSCLC) remains controversial. The aim of this study was to investigate the prognostic value of NLR and PLR before surgery in stage 1-2 NSCLC patients undergoing radical resection in our hospital. Materials and Methods: We included 59 patients with stage 1-2 NSCLC undergoing radical resection at our center between 2001 and 2014. The follow-up files of the patients were reviewed and necessary informations were obtained. Receiver operating curve (ROC) analysis was used for the optimal cut-off value of NLR and PLR (4.7 for NLR, 199 for PLR). The Kaplan-Meier univariate analysis was used to examine the effect of NLR and PLR on overall survival (OS) and disease-free survival (DFS). Results: There was no relationship between NLR and PLR classifications and clinical parameters except for age. OS mean was 53 months, DFS mean was 43 months in the group with NLR < 4.7, OS mean was 44 months and DFS mean was 28 months in the group with NLR> 4.7 (p = 0.031 for OS, p = 0.126 for DFS). OS mean was 55 months, DFS mean was 39.5 months in the group with PLR < 199, OS mean was 42 months, DFS mean was 30.6 months in the group with PLR > 199 (p=0,020 for OS, p=0,856 for DFS). Discussion and Conclusion: High pretreatment NLR and PLR values are independent predictors of poor prognosis in patients with opere lung cancer. Preoperative NLR and PLR values can be used as a prognostic parameter before radical resection in patients with stage 1-2 NSCLC.