The Relationship Between Neutrophil/Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) with Microalbuminuria in Participants with Different Glucose Tolerances

Abstract

Neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of subclinical inflammation for chronic diseases. Mean platelet volume (MPV) is a platelet function index. This study aimed to evaluate the relationship of NLR and MPV with microalbuminuria in participants with different glucose tolerances. 951 patients (male/female=302/649) were divided into five groups according to their oral glucose tolerance test (OGTT) results: group 1=normal glucose tolerance (NGT), group 2=impaired fasting glucose (IFG), group 3=isolated impaired glucose tolerance (IGT), group 4=both IFG and IGT, and group 5=type 2 diabetes mellitus (DM). Additionally, patients were divided into three groups according to their glycated hemoglobin (HbA1c) results: group 1=NGT, group 2=prediabetes, and group 3=type 2 DM. Outcomes were compared between groups. According to the OGTT, HbA1c, and OGTT+HbA1c criteria, there was a significantly positive correlation of microalbuminuria with MPV and NLR in all DM patients (p<0.001). Additionally, according to the OGTT, HbA1c, and OGTT+HbA1c criteria, there was a significantly positive correlation between MPV and microalbuminuria in all NGT patients (p<0.001). According to the OGTT and OGTT+HbA1c criteria, there was no significant correlation between NLR and microalbuminuria in prediabetic patients (p>0.05); however, there was a significantly positive correlation between NLR and microalbuminuria in the group with HbA1c 5.7–6.49 (p<0.001). Except isolated IFG and IGT, there was a significantly positive correlation between MPV and microalbuminuria in all prediabetic patients according to the OGTT, HbA1c, and OGTT+HbA1c criteria (p<0.001). NLR and MPV levels may be reliable predictive markers for the detection of microalbuminuria in prediabetes and DM.