Investigation of Vaspin and Visfatin -4689G/T Gene Polymorphisms in Alopecia Areata Patients

Abstract

Alopecia Areata (AA) is a chronic autoimmune condition that causes recurrent hair bereavement. Genetic and immunological factors act a part in the pathogenesis of AA. The aim of this study was to look into relationship between the vaspin and visfatin -4689G/T gene polymorphisms and AA sensibility in the Turkish population. This study included 80 AA patients and 80 healthy controls. Genomic DNA was extracted of blood samples Vaspin and visfatin -4689G/T gene polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The observed disparity in vaspin genotypes and allele distribution amid AA patients and healthy controls did not reach statistical significance (χ2 = 2.51, df = 1, p = 0.11 and χ2 = 1.75, df = 1, p = 0.18, respectively). Although visfatin GT genotype was higher in AA patients compared to control, it was not statistically significant. People with the visfatin GT genotype were more likely to be AA than people with the GG genotype [OR (95% CI) = 2.11 (1.04-4.27), p = 0.03]. This study shows that there is no affair amid vaspin and visfatin -4689G/T polymorphism and AA in the Turkish population. However, the TT genotype for the vaspin gene and the GT genotype for the visfatin -4689G/T gene are risk factors for people with AA disease.