The Relationship between High Sensitive C-reaction Protein (hs-CRP) and Diastolic Heart Function in Diabetes Mellitus Type II

Abstract

Among several inflammatory markers, high sensitive C-reaction protein (hs-CRP) is outstandingly observed in diabetic individuals. Serum hs-CRP is the main marker of inflammation whose levels independently predict the risk of cardiovascular events, and it has a prognostic value in heart patients. On the other hand, diabetes can lead to diastolic dysfunction of the heart. Diastolic dysfunction can cause symptoms of exertional dyspnea, which restricts the patient's activity. It is likely to predict diastolic dysfunction by screening through hs-CRP. The present investigation was a case-control study that was carried out on 52 patient diagnosed with diabetes mellitus type II. After the demographic data were recorded, and following the collection of data on the patients' history, physical examination, and para-clinical measures, individuals who had factors interfering with level of serum hs-CRP (kidney and liver diseases, inflammatory and infectious diseases, peripheral vascular disease, cerebrovascular disease, connective tissue disease, malignant tumor, trauma, consumption of statins, aspirin, ACEI, and fibrates) and diastolic dysfunction (ischemic heart disease, cardiomyopathies, pericardial disease, arrhythmias and valvular disease) were crossed out of the study. Serum hs-CRP was measured by nephelometry method. According to the results of tissue Doppler echocardiography, these patients are divided into two groups: one with diastolic dysfunction and the other without diastolic dysfunction. The serum hs-CRP levels of these patients were compared with each other. Among the participants, 30.8% were men and 69.2% were women, 36 individuals (69.2%) had diastolic dysfunction while 16 (30.8%) did not. There was a high level of correlation between the level of serumhs-CRP and diastolic dysfunction (p = 0.02, t = 2.36). The results of the present study indicated that there is a correlation between level of serum hs-CRP and diastolic dysfunction, such that the more the level of hs-CRP, the higher probability of diastolic dysfunction existence will be.