The relationship between forced expiratory volume 1 (FEV 1) with 25(OH) vitamin D level and hs-CRP in COPD in H. Adam Malik General Hospital Medan

Abstract

Background: The number of people with COPD according to WHO was increasing to 400 million people by 2020 and half of these occur in Indonesia. The incidence of COPD in Indonesia ranks 5th highest in the world at 7.8 million. COPD was a non-communicable disease that is thought to be closely related to the increasing number of smokers, especially in young age groups. This study aims to determine between FEV1 with 25 (OH) vitamin D level and hs-CRP in COPD patients.Methods: This study was a cross-sectional method conducted in H. Adam Malik General Hospital Medan, from January to June 2018 on 51 COPD patients who were treated at Pulmonology Outpatient Clinic. Spirometry examination, 25 (OH) levels of vitamin D, and hs-CRP was examined. Data were analyzed statistically using SPSS version 16 for windows.Results: Total 51 patients who participated in the study were all male. Based on Pearson Correlation Test, FEV1 value of COPD patients did not show a significant correlation with levels of 25 (OH) vitamin D. While the Spearman Rank Correlation Test shown significant correlation with hs-CRP levels. Anova test results and Kruskal Wallis test on levels of 25 (OH) vitamin D, hs-CRP and Leukocyte counts shown no significant differences with GOLD criteria. Conclusion: The mean FEV1 value of COPD patients, 25 (OH) levels of vitamin D and the number of Leukocytes shown no significant statistical difference, whereas the higher the FEV1value, the lower the hs-CRP.