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Abstract
BackgroundUp-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-reactive protein (CRP) expression.AimTo determine relationship between circulating concentrations of IL-17 and CRP in CSU.MethodsConcentrations of IL-17 in plasma and CRP in serum were measured in patients with CSU of varying severity and in the healthy subjects.ResultsIL-17 and CRP concentrations were significantly higher in CSU patients as compared to the healthy subjects. In addition, there were significant differences in IL-17 and CRP concentrations between CSU patients with mild, moderate-severe symptoms and the healthy subjects. CRP did not correlate significantly with IL-17.ConclusionsIncreased circulating IL-17 concentration may represent an independent index of systemic inflammatory response in CSU, which is not related to increased CRP concentration.
Highlights
Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU)
Increased circulating IL-17 concentration may represent an independent index of systemic inflamma‐ tory response in CSU, which is not related to increased C-reactive pro‐ tein (CRP) concentration
Plasma IL‐17 concentration Plasma concentrations of IL-17 were significantly higher in CSU patients as compared with the healthy subjects [median and quartile range/min–max: 21.97 (20.92– 24.98/18.85–62.73) vs. 19.88 (18.85–20.92/17.82–59.16) pg/ml, p < 0.001; Fig. 1]
Summary
Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). Chronic spontaneous urticaria (CSU) is a complex, systemic disease with a multifactorial etiopathogenesis associated with autoimmune and inflammatory phenomena [1,2,3]. It has been hypothesized that CSU is associated with a T helper cell 17 (Th17)—mediated immune response [4, 5], which is characterized by production of interleukin 17 (IL-17). Serum C reactive protein (CRP)—the best marker of acute phase response and IL-17 concentrations, may be associated with CSU activity [2, 5]. It has been suggested that IL-17-CRP signaling may play a role in chronic inflammatory conditions [9], its regulation and function in CSU have remained unclear. The aim of this study was to determine the relationship between circulating concentrations of IL-17 and CRP in CSU patients
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