The relationship between cardiac single-photon emission computed tomography imaging scores of latent Keshan disease and the parameters of cardiac biomarkers and echocardiography

Abstract

Objective To explore the relationship between cardiac single -photon emission computed tomography (SPECT) imaging scores of latent Keshan disease (LKD) and the parameters of cardiac biomarkers and echocardiography. Methods Ten patients with latent Keshan disease were examined with 99mTc-MIBI SPECT and echocardiography, left ventricle images were scored with 20 -segment model. The superoxide dismutase (SOD), malondialdehyde (MDA), and cardiac troponin I (cTnI) were measured with colorimetry and ELISA. Spearman correlation between cardiac SPECT image scores and the parameters was analyzed. Results The cardiac SPECT image of the patients with latent Keshan disease showed varied degrees of reduced intakes,the average of the four-category scores was (17 ± 4), ranged from 11 to 24. The average of the two-category scores was (13 ± 2), ranged from 9 to 17. Spearman correlation analysis showed that SPECT four-category scores and two-category scores were not statistically correlated with SOD, MDA and cTnI (r = -0.35, 0.25, 0.27, 0.00, 0.34 and 0.08, all P > 0.05). Spearman correlation analysis showed that SPECT four-category scores were statistically correlated with left ventricular end-diastolic volume (LVEDV) and left ventricular mass (LVM) (r = 0.71, 0.77, all P < 0.05); two-category scores were significantly correlated with left ventricular posterior wall thickness (LVPWT), left ventricular cardiac output (CO), LVEDV, left ventricular end-systolic volume (LVESV) and LVM (r = 0.81, 0.75, 0.86, 0.79 and 0.83, all P < 0.05). Conclusions The cardiac SPECT images of the patients with LKD have showed reduced uptake by myocardial. SPECT scores are in good consistency with the parameters of echocardiography although they are not correlated significantly in statistics with the parameters of cardiac biomarkers. Key words: Latent Keshan disease; Single-photon emission computed tomography; Score; Cardiac biomarkers; Echocardiography