The relationship between body mass index, lipid profile and non-alcoholic fatty liver disease in healthy check-up crowd

Abstract

Objective To analyze the relationship between body mass index, lipid profile and non-alcoholic fatty liver disease (NAFLD). Methods A population-based, cross-sectional study was carried out in 10 000 clients of health examination in the population of Hefei area in 2012. Body mass index (BMI), history of alcohol intake and past medical history were recorded. Subjects were divided into four groups according to the levels of BMI, clinical indicators included serum lipids, and fasting blood glucose and the rate of non-alcoholic fatty liver disease were compared among the four groups. Distribution of BMI of the masses in Hefei region was analyzed. The relationships between BMI and the incidences of hyperlipidemia and non-alcoholic fatty liver disease were discussed. Results (1)The occurring rate of obesity and overweight was 60%, normal weight was 38.3%. (2)The incidence of overweight and obesity was distinct in different age groups (χ2=161.733, P=0.000). (3)Except for high density lipoprotein-cholesterol, indicators included triglyceride, total cholesterol, low density lipoprotein-cholesterol, fasting blood sugar and uric acid levels in overweight and obesity groups were significantly higher than those in normal group. (4)With the increasing of BMI, the incidence of non-alcoholic fatty liver disease and hyperlipidemia were increased. (5)Factors including BMI, gender (male), triglyceride, total cholesterol were independent risk for non-alcoholic fatty liver disease, whereas high density lipoprotein cholesterol was a protective factor. (6)ROC analysis demonstrated that the best cut off value of BMI in predicting the incidence of non-alcoholic fatty liver disease was 24.85 or 24.95 in male and 24.95 in female. Conclusions Overweight and obesity are the risk factors for the prevalence of NAFLD and hyperlipidemia. Management of weight and targeted interventions rectifying the metabolism disorders at the earliest opportunity, which may contribute to reduce the risk of hyperlipidemia and NAFLD. Key words: Obesity; Overweight body; Body mass index; Dyslipidemia; Non-alcoholic fatty liver disease