Association of nonalcoholic fatty liver disease and albuminuria in patients with type 2 diabetes mellitus

Abstract

Objective To investigate the prevalence and risk fatcors of nonalcoholic fatty liver disease (NAFLD) and its relationship with albuminuria in in-patients with type 2 diabetes mellitus (T2DM).Methods A total of 1 205 in-patients with T2DM were enrolled in this study.The patients were divided into NAFLD group and nonNAFLD group by mean of liver uhrasonography,and into negative albuminuria group (NA) and albuminuria group (AU) according to albumin-to-creatinine ratio.The general information and laboratory data of patients were collected.Chi-square test and binary logistic regression analysis were conducted.Results (1) The prevalence of NAFLD in the patients with T2DM was 60.8％.Binary logistic regression revealed that NAFLD was positively correlated with triglyceride,body mass index (BMI),fasting plasma glucose,waist circumference,diastolic blood pressure,and systolic blood pressure (SBP),and negatively correlated with serum creatinine,duration of diabetes,AU,and high density lipoprotein-cholesterol (HDL-C,all P＜0.05).(2) The prevalence of AU was 31.0％ in these patients.Binary logistic regression revealed that AU was positively correlated with total cholesterol (TC),HbA1C,BMI,duration of diabetes,SBP,and creatinine; and negatively correlated with NAFLD and HDL-C (all P ＜0.05).(3) As subjects were divided into three groups based on their age,the prevalence of NAFLD was decreased and that of AU was increased with aging and diabetes duration (all P＜0.05).The prevalence of NAFLD in patients with AU was significantly lower than that in patients without AU (53.4％ vs 64.2％,P＜0.05).Partial correlations analysis indicated no significant correlation between NAFLD and AU after being adjusted by age and duration of diabetes(P＞0.05).Conclusions With aging and prolonged diabetes,the prevalence of NAFLD is decreased and that of AU is increased.NAFLD is negatively correlated with AU,but this correlation does disappear after adjustment for age and duration of diabetes. Key words: Diabetes mellitus, type 2;  Nonalcoholic fatty liver disease;  Albuminuria