Abstract
The study aimed to determine the effect of changes in apelin hormone in patients with diabetes of both types, and the positive impact when increasing its concentration in the body, the study included 136 patients of various ages which compared with 25 healthy individual as control group, The results showed that:
 There was a significant increase in the apelin conc. (P≤0.05)in diabetic patients type 2 compared with control group and type 1.
 And there was a significant increase (P≤0.01) in the glucose concentration compared with control group,
 And a significant decrease (P≤0.01) in glutathione conc. compared with the control.
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