Evaluation of Liver Enzymes Activities among Type 2 Diabetic Patients, Attending Alribat University Hospital, Khartoum State

Abstract

Background: Diabetes mellitus is a metabolic disease known by chronic hyperglycemia which results from defective insulin action and secretion. Various studies have documented liver disease as a major cause of mortality in patients with type 2 diabetes. It is well known that the liver plays an important role in the maintenance of normal glucose levels during fasting as well as in the postprandial period Aim: To evaluate the levels of liver markers in type 2 diabetes patients in Khartoum state. Materials and Methods: The study was conducted in Alribat University hospital, Sudan during the period from January 2018 to April 2019. Hundred subjects were included in the study, fifty patients previously diagnosed with Type 2 diabetes and similar number of age- andgender-matchedhealthy control subjects. The design of the study was cross-sectional, with a retrospective historical review through apersonal interview of all subjects.Blood was collected in a heparinized tube at room temperature and centrifuged for 10 minutes at 3500rpm, Serum liver markers concentrations were estimated by an enzymatic method in a fully Automated Biochemistry Analyzer (Cobas 3546). The data were analyzed using SPSS version 20.Results: The majority of patients were > 55 years. serum level of AST in type 2 diabetic patients and control group respectively were (31.26±10.34, 20.35±6.48) p value= 0.00), serum levels of ALT in type 2diabetic patients and control group respectively were (33.74±6.48, 19.70±6.23) p value= 0.00, serum level of ALP in Type 2 Diabetes patients and control group respectively were (125.20±49.61, 87.90±24.35) p value= 0.00,Serum level of GGT in Type 2 Diabetes patients and control group respectively were (47.72±9.01, 43.48±8.63) p value= 0.026. The mean BMI in type 2 diabetic patients and the control group respectively were (26.36±5.94,19.19±2.67), p value= 0.00, the correlation between duration of disease and liver enzymes GGT,ALT,AST and ALP respectively were (0.47,0.34,0.57,0.93). The current study showed in significant correlation between serum (GGT and ALT) and BMI of patients among type 2 diabetic patients (p value= 0.83,0.863) but significant correlation between serum (AST, ALT) and BMI of patients ( p value= 0.002,0.032).Conclusion: In the present study, a significant increase in the level of liver enzymes, ALT, AST, GGT ALP was observed in type 2 diabetic patients when compared to the normal group. Hence, we found an association between the level of liver enzymes, ALT, AST, and GGT in type 2 diabetic patients. Thus, these liver enzymes can be used as biomarkers for the assessment of type 2 diabetes, and we found no association between the level of liver enzymes, ALT, AST, and GGT in type 2 diabetic patients and duration of disease.