The relationship between 2D:4D ratio and postpartum adult female variables in a Ghanaian population.

Abstract

Postpartum hematological and anthropometric assessment is a requirement for optimal maternal and child health. The study aimed to determine the relationship between the 2D:4D ratio and postpartum hematological and anthropometric variables in adult females. The study was cross-sectional from December 2020 to April 2021 involving 272 postpartum adult females, aged between 18 and 36 years. The right (2D:4DR) and the left (2D:4DL) digit ratios were measured using computer-assisted analysis. Fasting venous samples were collected at a median (interquartile range) of 111 (44-210) days postpartum and analyzed for total testosterone (TT), estradiol, sex hormone-binding globulin, and complete blood count. The mean ± standard deviation 2D:4DR and 2D:4DL were 0.94 ± 0.04 and 0.93 ± 0.04, respectively. As expected, the TT (r=-0.198, p=.015) and the free androgen index (FAI: r=-0.186, p=.019) were inversely correlated with the 2D:4DL while free testosterone (FT%: r=-0.157, p=.038) was inversely correlated with the 2D:4DR. The absolute basophile count (BASO: r=-0.124, p=.040) and the Platelet-lymphocyte ratio (PLR: r=-0.153, p=.016) were inversely correlated with the 2D:4DL and the 2D:4DR respectively. In addition, the mean cell volume was inversely correlated with the 2D:4DR (r=-0.139, p=.024) and the 2D:4DL (r=-0.122, p=.045). Moreover, the 2D:4DR was inversely correlated with height (r=-0.164, p=.007). Unexpectedly, the red blood cell count (RBC: r=0.138, p=.025) was positively correlated with the 2D:4DR. There are significant relationships between the 2D:4D ratio and postpartum female variables. These findings are useful preliminary reference data for postpartum research and subsequent 2D:4D ratio studies.