Abstract
Huang T-S, Wang Y-H, Chen S-Y. The relation of serum leptin to body mass index and to serum cortisol in men with spinal cord injury. Arch Phys Med Rehabil 2000;81:1582-6. Objective: To investigate the relations among serum leptin, body mass index (BMI), and various hormone levels in men with spinal cord injury (SCI). Design: Cross-sectional. Setting: University hospital that is a tertiary referral center. Participants: Forty-seven men with traumatic neurologically complete SCI and 47 age- and BMI-matched male controls. Main Outcome Measures: Baseline levels of various hormones were measured in subjects with SCI. Serum leptin and cortisol levels and BMI were measured in both groups. Results: Serum leptin was significantly higher in the group with SCI than in the control group. A linear relation was found between serum leptin and BMI in both groups separately. A polynomial relation was found between serum leptin level and BMI in the group with SCI. A “J” phenomenon is noted at the lowest BMI. Serum cortisol correlated significantly with serum leptin level in the group with SCI. Conclusion: Sympathetic denervation, peripheral nerve palsy, recurrent infections, and possible central neurotransmitter alterations after SCI may contribute to the elevation of serum leptin level in men with SCI. © 2000 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation
Published Version
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