Abstract
PURPOSE To investigate the relation of physical activity, bone markers, and ultrasound transmission velocity (UTV) at the calcaneus in older adults. METHODS Participants were 516 community-dwellers (365 men and 151 women) with a mean age of 76 ± 5(SD) year. Amount of physical activity in previous one year was assessed using the “Modified Baecke Questionnaire”. Bone-markers were assessed including serum osteocalcin (OC), bone-specific alkaline phosphatase (bALP), intact parathyroid hormone (iPTH), urine deoxypyridinoline (uDPD), and urine type I collagen N-telopeptide breakdown products (uNTX). Bone density was assessed by UTV at right calcaneus. Daily dietary calcium intake, coffee intake, smoking, and use of medications for osteoporosis were also assessed by questionnaires. RESULTS Older women had higher OC (median, 25th-75th percentiles;4.3, 2.7–6.3 ng/mL vs. 2.7, 1.6–4.0 ng/mL, P < 0.05), bALP (16.2, 11.8–24.1 ug/L vs. 13.6, 10.3–18.1 ug/L, P < 0.05), uDPD (9.7, 7.7–12.1 nM/mM creatinine vs. 5.7, 4.9–7.0 nM/mM creatinine, P < 0.05), uNTX (57.6, 39.6–72.3 nM BCE/mM creatinine vs. 29.6, 21.4–38.2 nM BCE/mM creatinine, P < 0.05), and lower UTV (1784, 1732–1858 m/s vs. 1809, 1744–1870 m/s, P < 0.05) and physical activity score (4.02, 1.96–8.28 vs. 7.46, 3.65–12.22, P < 0.05) than men. Multivariate regression analyses revealed markers of bone resorption (uDPD and uNTX) were negatively correlated with physical activity score in men (P < 0.05), but no association was found in women. No associations among physical activity score, markers of bone formation (OC and bALP), and UTV were observed in each gender. CONCLUSION Older women have higher bone turnover rates then older men. The results imply that older men should increase daily physical activities to prevent osteoporosis. Further studies are needed to clarify the role of exercise in prevention of osteoporosis among older women. Supported by NSC 89-2314-B-002-464- and NTUH.S90-1500-65
Published Version
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