Abstract
Type 2 diabetes mellitus(T2DM) is a metabolic disease that is associated with an increased risk for atherosclerosis by 2-4 folds than in non- diabetics. In general population, low IGF-1 has been associated with higher prevalence of cardiovascular disease and mortality .This study aims to find out the relationship between IGF-1 level and other biochemical markers such as Homeostasis Model Assessment insulin resistance(HOMAIR) and Body Mass Index(BMI) in type 2 diabetic patients . This study includes (82) patients (40 females and 42 males) with age range (40-75) years,(34) non obese diabetic patients and (48) obese diabetic patients. The non obese individuals considered as a controls group, all controls and patients groups with type 2 DM, ischemic heart disease and hypertension, and free from other disease by history and clinical exam .The results showed that serum IGF-1 levels were lower in obese diabetic patients than non obese.HOMAIR has been found to be significantly higher in obese than non obese diabetic patients ,there is negative correlation between IGF-1 and HOMAIR. Body mass index (BMI) was in positive correlation with HOMAIR and innegativecorrelationwithIGF-1. Conclusion of this study was the serum level of IGF-1 is significantly lower in obese than non obese type 2 DM , but HOMA IR is significantly higher in obese diabetic subjects .
Highlights
Diabetes mellitus is a group of metabolic diseases which characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both, the chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels, that impose a tremendous burden on the individual with diabetes and on the health care system [1] .Type 2 DM is a heterogeneous group of disorder characterized by variable degrees of insulin resistance, insulin secretion, and increased glucose production[2].Insulin resistance is an impaired response to normal levels of exogenous or endogenous insulin in cells of the whole body, insulin resistance has been implicated in the pathogenesis of the metabolic syndrome [3]
Samin et al [14]; studied that IGF-1 concentrations were significantly lower with increase obesity (BMI ≥35 ), which is in agreement with our results which showed that obese patients have lower level of IGF-1 when the Body mass index (BMI) is increase .The present study demonstrated a statistically significantly low level of IGF-1 in patients with obesity compared with control subjects,but Nam
IGF-1 level is significantly lower in obese diabetic patients,but negatively correlated with BMI in both groups .These results collectively support the hypothesis that hyperinsulemia may contribute to insulin resistance in obesity
Summary
Diabetes mellitus is a group of metabolic diseases which characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both, the chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels, that impose a tremendous burden on the individual with diabetes and on the health care system [1] .Type 2 DM is a heterogeneous group of disorder characterized by variable degrees of insulin resistance, insulin secretion, and increased glucose production[2].Insulin resistance is an impaired response to normal levels of exogenous or endogenous insulin in cells of the whole body, insulin resistance has been implicated in the pathogenesis of the metabolic syndrome [3]. Obesity, especially upper body obesity, physical inactivity, fat storage defects, male hormones, aging, and genetic factors may lead to the impairment of insulin action. Insulin –like growth factor it's called Somatomedin C., which is polypeptide protein hormone with high sequence similarity to insulin[9] .Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues[9].IGF-1 receptor is heterotetramer that is homologues to the insulin receptor. The intracellular β chains have tyrosine kinas activity that is activated upon ligand binding[10].The somatomedines mediate many of growth promoting effects of GH via the IGF-1 receptor which can restore growth in GH-
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