Abstract
Background: Visfatin is a newly discovered cytokine that is highly expressed in visceral fat with a direct relationship to type 2 diabetes mellitus (T2DM). The present study was conducted to demonstrate the relationship between plasma visfatin level and T2DM whether in obese or non obese patients. Subjects and methods: This prospective study was carried out on 74 subjects divided into 4 groups. Group I: Twenty obese non diabetic patients, Group II: Twenty obese diabetic patients, Group III: Twenty non obese diabetic patients and Group IV: Fourteen age and gender matched apparently healthy subjects to serve as controls. All patients and controls were subjected to full history taking, complete clinical examination, routine laboratory investigations, fasting serum insulin, homeostasis model assessment of insulin resistance (HOMAIR) and serum visfatin level. Results: Serum visfatin level was significantly increased in the obese subjects and in the diabetics with the highest rise in the obese diabetics suggesting that serum visfatin level has a link between obesity and T2DM. Also, there was a significant positive correlation between serum visfatin level and body mass index (BMI), serum insulin & HOMAIR. Conclusion: There may be a possible role of visfatin in the Pathophysiology of insulin resistance, T2DM and obesity.
Highlights
The incidence of Type 2 diabetes mellitus (T2DM) continues to increase dramatically in most parts of the world, and the ways to prevent or cure the disorder are limited despite enormous research efforts [1]
There may be a possible role of visfatin in the Pathophysiology of insulin resistance, type 2 diabetes mellitus (T2DM) and obesity
body mass index (BMI) showed significant increase in Group II patients compared with group I patients (p0.05)
Summary
The incidence of Type 2 diabetes mellitus (T2DM) continues to increase dramatically in most parts of the world, and the ways to prevent or cure the disorder are limited despite enormous research efforts [1]. Adipose tissue produces several proteins (adipocytokines) such as leptin, adiponectin, resistin, TNFα, IL-6 and visfatin that modulate insulin sensitivity and appear to play an important role in the pathogenesis of insulin resistance, diabetes, dyslipidemia, inflammation, and atherosclerosis [3]. Visfatin is a newly discovered adipocyte hormone with a direct relationship to T2DM This hormone is found in the cytoplasm as well as the nucleus of cells and has been identified in many tissues and organs including the brain, kidney, lung, spleen and testis but preferentially expressed in visceral adipose tissue [4]. Visfatin is a newly discovered cytokine that is highly expressed in visceral fat with a direct relationship to type 2 diabetes mellitus (T2DM). The present study was conducted to demonstrate the relationship between plasma visfatin level and T2DM whether in obese or non obese patients
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