The Relation Between Endoscopic and Subjective Laryngopharyngeal Reflux Signs, Vocal Tract Discomfort, Voice Handicap, and Voice Disorder Type: Same Yet Different?

Abstract

ObjectivesThis study aimed to investigate the relation between subjective voice-related symptoms and endoscopic findings in patients with different etiology of voice disorder and vocally healthy subjects with and without laryngopharyngeal reflux (LPR). Study designretrospective cross-sectional study MethodsThe study involved 149 participants (106 female, 43 male) including 125 with various voice disorders (functional, structural and neurogenic) and 24 vocally healthy individuals. For self-rating the German versions of the Voice Handicap Index (VHI), Vocal Tract Discomfort (VTD) Scale, and Reflux Symptom Index (RSI) were applied, while endoscopic evaluations utilized the Reflux Finding Score (RFS) and Reflux Sign Assessment (RSA).Statistical analyses incorporated ANOVA with Bonferroni post-hoc tests to identify group variations. Correlations between VTD Scale, VHI, RSI, RFS and RSA were evaluated using Pearson’s correlation coefficient. To examine test sensitivity and specificity for the VTD Scale and RSA, we performed a ROC analysis. Youden’s-Index was applied to determine the cut-off-value with best discriminatory abilities. The diagnosis of LPR was assumed when the criteria of RFS > 7 AND RSI > 13 was met. ResultsSignificant differences for all voice diagnosis groups and vocally healthy individuals for RFS and all three self-rating questionnaires were found. Moreover, there was significant correlation between VTD Scale and VHI and RSI as well as RSI and RFS, which was moderate, negative in the group of persons with LPR. However, there was no significant difference for RSA results between the vocally healthy or any diagnosis group. ConclusionThus, the RFS may be more suitable to predict reflux and voice related symptoms. The VTD Scale is a useful instrument in screening voice disorders but also LPR and can therefore be used as a tool for decision making when transferring to a specialist.