Abstract
Ischemic stroke is one of the leading causes of global mortality and disability. It is a multi-factorial disease involving multiple factors, and gene dysregulation is considered as the major molecular mechanisms underlying disease progression. Angiogenesis can promote collateral circulation, which helps the restoration of blood supply in the ischemic area and reduces ischemic necrosis following ischemic injury. Aberrant expression of long non-coding RNAs (lncRNAs) in ischemic stroke is associated with various biological functions of endothelial cells and serves essential roles on the angiogenesis of ischemic stroke. The key roles of lncRNAs on angiogenesis suggest their potential as novel therapeutic targets for future diagnosis and treatment. This review elucidates the detailed regulatory functions of lncRNAs on angiogenesis following ischemic stroke through numerous mechanisms, such as interaction with target microRNAs, downstream signaling pathways and target molecules.
Highlights
Stroke is a type of acute cerebral vascular disease with high disability and mortality rate
Silenced MEG8 inhibited the viability, migration and angiogenesis of BRAIN MICROVASCULAR ENDOTHELIAL CELLS (BMECs) via targeting miR-130a5p. These findings suggested that MEG8 could protect BMECs from oxygen/glucose deprivation (OGD)-induced injury by promoting the angiogenesis following ischemic stroke through the miR-130a-5p/VEGFA axis (Sui et al, 2020)
Emerging evidence has suggested that long non-coding RNAs (lncRNAs) serve essential roles in the pathogenesis of ischemic stroke
Summary
Ischemic stroke is one of the leading causes of global mortality and disability. It is a multi-factorial disease involving multiple factors, and gene dysregulation is considered as the major molecular mechanisms underlying disease progression. Aberrant expression of long non-coding RNAs (lncRNAs) in ischemic stroke is associated with various biological functions of endothelial cells and serves essential roles on the angiogenesis of ischemic stroke. The key roles of lncRNAs on angiogenesis suggest their potential as novel therapeutic targets for future diagnosis and treatment. This review elucidates the detailed regulatory functions of lncRNAs on angiogenesis following ischemic stroke through numerous mechanisms, such as interaction with target microRNAs, downstream signaling pathways and target molecules.
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