Abstract
Epilepsy is a neurological disease characterizedby neural network dysfunction.Although most reports indicate that the pathological process of epilepsy is related toinflammation, synaptic plasticity, cell apoptosis, and ion channel dysfunction, the underlyingmolecular mechanisms of epilepsy are not fully understood. This review summarizes the latest literature on the roles and characteristics of longnoncoding RNAs (lncRNAs) in the pathogenesis of epilepsy. lncRNAs are a class of long transcripts without protein-coding functions that performimportant regulatory functions in various biological processes. lncRNAs are involved in theregulation of the pathological process of epilepsy and are abnormally expressed in bothpatients and animal models. This review provides an overview of research progress inepilepsy, the multifunctional features of lncRNAs, the lncRNA expression pattern related toepileptogenesis and status epilepticus, and the potential mechanisms for the two interactionscontributing to epileptogenesis and progression. lncRNAs can serve as new diagnostic markers and therapeutic targets for epilepsy in thefuture.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call