Abstract
The levels of cellular and extracellular cyclic AMP-phosphodiesterase activity in preaggregation cells of three species of the cellular slime mold Dictyostelium were found to be elevated by the addition of exogenous cyclic AMP. This increase in enzyme activity appeared to be due largely to the ‘turn-off’ of the synthesis of its specific inhibitor. In addition to regulating the production of cyclic AMP-phosphodiesterase and its inhibitor, elevated concentrations of cyclic AMP also prolonged cell aggregation. These observations suggests that the extracellular phosphodiesterase-inhibitor system of Dictyostelium might be involved in regulating the level of extracellular cyclic AMP in cell populations prior to aggregation.
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